What is Anemone hepatica?
Anemone hepatica, Also known as hepatica nobilis, liverwort anemone o liverwort, is a perennial herbaceous plant of the Ranunculaceae family. Its name comes from the characteristic shape of its trilobed leaves, reminiscent of the liver, which has historically linked it to liver ailments. This small plant usually does not exceed 20 cm in height and is easily recognized by its thick, leathery leaves and flowers that vary in color. blue to white or pink.
Its leaves, firm and dense, present a dark green upper surface with whitish spots and a purplish or greenish underside, covered with soft hair. They are supported by long petioles that emerge directly from the underground rhizome. The flowers appear before the surrounding trees unfurl their leaves, taking advantage of the early spring light. They are usually made up of 6 to 8 tepals and are solitary, rising on hairy stalks that often exceed the length of the leaves.

Habitat and distribution
The liverwort anemone grows wild in humid forests in temperate regions of the northern hemisphere.It is especially abundant in cool holm oak, oak, and beech forests, as well as in damp pine forests. It prefers calcareous soils and adapts to siliceous substrates, growing in both lowland and mountainous areas, from a few meters above sea level to higher altitudes.
This plant is usually found in shady, damp places, emerging after the thaw, in spring, or even in the late winter months where the climate permits. It is less common in dry environments, although adapted specimens do exist. Early flowering allows it to avoid competition with other later-flowering forest species and take advantage of the activity of the first pollinating insects of the year.
Chemical composition
Among the most notable components of Anemone hepatica are:
- Protoanemonin: toxic alkaloid present in the fresh plant, responsible for its toxicity and skin irritation.
- Anemonin: the resulting compound after drying, which is less toxic and mostly harmless.
- Hepatotrilobin: glycoside with possible medicinal effects.
- Saponosides and tannins: responsible, in part, for the diuretic and astringent effects.
- Flavonoids and mucilages: contribute to its antioxidant, anti-inflammatory and mucous membrane-protective properties.
It is important to note that the plant fresh is blistering and toxic, which can cause skin and mucous membrane irritation, vomiting, diarrhea and, in severe cases, neurological problems such as paralysis.

History and traditional uses
Anemone hepatica has a long tradition in folk medicine, closely linked to the theory of signatures, which was thought to be useful for treating a body part that resembled one of its parts. Thus, the resemblance of the three-lobed leaves to the liver led to the liverwort being considered a remedy for liver ailments.
In the past, it was used for:
- Treat liver and biliary diseases (based on tradition, although without scientific validation).
- Relieve cough, bronchitis and lung conditions.
- Reduce intestinal inflammations and act as diuretic.
- Treat hemorrhoids and minor digestive discomfort.
- Apply externally for wounds, eczema and boils thanks to its healing effect.
- In ancient times they were prepared poultices, washes or plasters with the dried or powdered leaves to treat skin conditions.
Currently, several health authorities, including the German Commission E, advise against its medicinal use due to the lack of solid scientific evidence and the risk associated with its toxicity, especially if administered fresh or in high doses.
Medicinal properties: what science and tradition say
Among the properties recognized in tradition and in lists of medicinal plants are:
- Diuretic: It helps eliminate fluids and toxins through urine, contributing to reduce inflammation and better kidney function.
- Intestinal anti-inflammatory: Provides relief in cases of inflammation or irritation of the intestinal tract.
- Vulneraria (healing): Applied externally in the form of washes, poultices or plasters, it helps to wound healing, eczema, boils, sores and skin ulcers.
- Antispasmodic and antioxidant: Thanks to its flavonoid content, it helps reduce cramps and protects cells from oxidative damage.
- Astringent: Its tannins give it an astringent effect, useful in cases of mild diarrhea or mucous membrane problems.
Some ancient texts also cite it as an ally against bronchitis and other respiratory conditions, although these uses have not been scientifically proven and should be viewed with caution.

Methods of preparation and administration
According to popular experience and traditional phytotherapy, Anemone hepatica is commonly used in the following forms:
- Infusion: One teaspoon of dried leaves per cup of hot water. It is recommended to drink two to three cups a day to benefit from its diuretic and anti-inflammatory properties. It can also be applied externally in the form of washes or compresses for skin conditions or conjunctivitis.
- Maceration: The dried leaves can be soaked in water or wine at room temperature overnight; the following day, it is taken on an empty stomach. The traditional dosage is about three grams of dried plant in 100 ml of water or wine.
- Poultices and powders: The dried leaves can be crushed to form powders that are applied to wounds, sores, or eczema.
Important warning: The plant should never be used fresh or in high doses due to the presence of protoanemonin, which can be dangerous and cause serious side effects such as vomiting, diarrhea, abdominal pain, mucous membrane irritation, and even skin blisters. The dried plant should always be used to minimize risks.
Possible Side Effects and Precautions
Like many species in the Ranunculaceae family, the Anemone hepatica contains potentially irritating and toxic substances. The following recommendations should be taken into account:
- Avoid consumption of the plant fresh orally or topically, as it is a blister and can cause serious discomfort.
- Prolonged or excessive use may cause kidney and urinary tract irritation, digestive discomfort, vomiting, diarrhea and stomach pain.
- May appear blisters, itching, redness, or swelling on the skin when applying fresh or concentrated preparations.
- Its use is not recommended during pregnancy and lactation, except under the supervision of a qualified professional.
- It should not be administered to young children or people with kidney or liver disease without medical supervision.
Phytotherapeutic authorities, such as the aforementioned Commission E, have concluded that the risks outweigh the potential benefits and recommend avoiding self-medication with this plant.

Confusions and myths about liverwort
For centuries, Anemone hepatica was considered a remedy for the liver because of the similarity of its leaves to this organ, which exemplifies one of the most deeply rooted beliefs of traditional herbalism: the theory of signatures. Currently, it is known that It has no direct protective or stimulating effects on liver function, and this idea has been disproved by modern science.
Another common myth is that its use is completely safe because it is a natural plant, which it is not true: The toxicity of Anemone hepatica, if not prepared properly, can be considerable.
Curiosities and other names
- Other common names: Golden clover, Trinity herb, liverwort, wolfsbane, golden trefoil, among others.
- The plant is known and appreciated in many European countries and appears in modern botanical records under the names hepatica nobilis y Anemone hepatica (currently considered synonyms).
- The Anemone hepatica is a hardy plant, capable of surviving the coldest winters and blooming early in the year, thanks to physiological adaptations that allow it to take advantage of the limited spring light before the trees develop their foliage.
La Hepatic anemone It combines a fascinating blend of natural beauty, history, mythology, and medicinal properties. Although its use has been displaced today by caution regarding its toxicity and the lack of solid clinical evidence regarding its supposed liver benefits, popular tradition still considers it a special plant. Its use should always be based on informed judgment, using it only dried and in appropriate doses, and preferring its external use for minor skin lesions or inflammations. The botanical and cultural information about this plant continues to inspire naturalists, herbalists, and phytotherapy enthusiasts around the world.