Introduction to Lactuca virosa: What is wild lettuce?
lactuca virosa, commonly known as wild lettuce o wild lettuce, is a plant belonging to the family Asteraceae, widely recognized for its traditional properties and ethnobotanical value. Similar in appearance to cultivated lettuce (lactuca sativa), distinguished by its robustness, presence of milky latex, and unique chemical compounds, which have made it an object of study and medicinal use since ancient times. Native to temperate zones of Europe and Asia, and later naturalized in other regions, Lactuca virosa stands out for both its biology and its therapeutic applications.
This biennial species produces a latex called lactucarium, a substance with a bitter taste and penetrating odor, which has historically been used as a natural sedative and sleeping pill. Wild lettuce has received names over the centuries such as lettuce opium due to its mild narcotic effects and its use as an alternative to opium in various cultures.
Taxonomy and botanical classification

- Kingdom: Plant
- Division: Magnoliophyta
- Class: Magnoliopside
- Order: Asterals
- Family: Asteraceae
- Gender: lactuca
- Species: lactuca virosa L.
There are numerous synonyms due to the morphological variability of the species and the history of its classification. Alternative names include Lactuca ambigua, Lactuca flavida y Roman Lactuca, among others. In different languages ​​and regions, it is known by terms such as wild lettuce, poisonous lettuce, poison lettuce o lettuce border, reflecting both its appearance and its properties.
Morphological description of Lactuca virosa
lactuca virosa is a biennial plant which can reach between 1 and 2 meters in height, characterized by its straight, robust, hollow and often branched stem, which becomes noticeably smooth and greenish, and can take on purple tones under environmental stress, such as cold.
The leaves are alternate, elongated, and lanceolate, with serrated or slightly spiny edges depending on the variety. The underside of the leaves usually has a central vein covered with fine hairs. The lower leaves can measure up to 25 cm, while the upper ones are smaller.
The inflorescence consists of a spike of small, pale yellow flower heads reminiscent of dandelions. Flowering occurs primarily in late summer, and each flower is composed of six to twelve smaller flowers. The fruits are small, black achenes that allow for wind dispersal.
One of the most distinctive features of Lactuca virosa is its milky latex (lactucarium), which exudes abundantly when cuts are made in stems and leaves, turning brown upon contact with air.
Geographic distribution and habitat
Lactuca virosa is found in temperate zones of Europe, especially in countries of Central and Southern Europe and the British Isles (most abundantly in the Southeast and East of England). It has also become naturalized in regions of Western asia (including Pakistan, India and Iran) and has subsequently spread to Australia y North America (where it was introduced by humans and can be found in states such as California, Iowa, Alabama and Washington).
The plant prefers moist, well-drained environments, often near rivers and areas with calcareous, sunny soils, although it can thrive in shaded and sheltered areas. It is commonly found on roadsides, meadows, cultivated fields, and disturbed soils, demonstrating great adaptability to different environmental conditions.
Biological cycle and cultivation
Lactuca virosa follows a cycle biennialDuring the first year, it produces a rosette of basal leaves; in the second season, it develops a flower stalk that grows rapidly to its full height. It then flowers and bears fruit, dispersing its seeds before completing its life cycle.
For cultivation, the plant requires well-drained soils rich in organic matter and constant moisture. It prefers sunny locations, although it tolerates partial shade. The latex or aerial parts are usually harvested during flowering, when the concentration of active ingredients is highest.
It propagates by seed, which can be sown directly in the ground or in seedbeds, after which the seedlings are transplanted when they are sufficiently developed. It is important to allow sufficient space between plants due to their size and leaf development.
Chemical composition: Active ingredients
Lactuca virosa stands out for its richness in bioactive compounds:
- Lactucin and lactupicrin: sesquiterpene lactones responsible for much of its sedative and calming effects.
- Lactucerol: an ester present in lactucarium.
- Lactucarium: the milky latex rich in bitter substances that is obtained by incising the stems.
- Alkaloids, organic acids, alcohols, enzymes and mannitol make up its chemical profile, along with other neutral and insoluble substances such as lactocrine. You can find out more about Lactuca serriola.
El lactucarium It contains around 0,2% lactucin in its sap. The active compounds act as adenosine receptor agonists, which explains its sedative and relaxing effects. Lactucarium also contains a high proportion of rubber, mannitol, and lactucerol, up to 50% of its composition.
Medicinal properties and traditional uses

The traditional use of Lactuca virosa covers cultures in Europe, Asia and Africa, where it was used mainly for its narcotic, sedative, hypnotic and calming effects. The lactucarium It was historically used in the form of an infusion, tincture, or dry extract, both to relieve insomnia and to calm nervous excitement, pain, and anxiety disorders. Discover other medicinal plants for a sustainable garden.
Among its most notable applications:
- Sleep aid and anxiolytic: used as a natural sleeping pill before the advent of synthetic hypnotics and opium.
- Analgesia: relief of mild to moderate pain, rheumatic conditions and joint discomfort.
- Muscle relaxant: Its action on the central nervous system promotes rest and reduces physical tension.
- Antitussive and throat soothing effects: traditionally recommended in cough relief preparations.
Despite its similarity to opium in effects, lactucarium It does not cause physical or psychological dependence. However, its use must be cautious and informed, as excessive consumption can cause profound drowsiness and even respiratory risks.
History and ethnobotany of Lactuca virosa
The use of wild lettuce dates back to old times Such as Egypt, where it was cited in papyri as a remedy for various ailments. In classical Greece and Rome, authors such as Dioscorides already mentioned it, describing it as "a friend of the stomach, a sleep aid, and a softener of intestinal transit." Its presence was significant in medieval pharmacopoeia, documented as part of the crops recommended by Charlemagne.
In Eurasia, especially in the Caucasus and Turkestan, its use was associated with mystical and spiritual practices: dervishes used the latex pure or combined with hashish to achieve altered states of consciousness and visions. During the centuries prior to modern medicine, European physicians and apothecaries used extracts of lactuca virosa as a substitute for opium when it was scarce.
Even in more recent times, such as in rural areas of France and Spain, a decoction of the stems and leaves was a well-known household remedy for inducing sleep and calming children and adults.
In the second half of the 20th century, it became popular in the United States under names such as "lettuce opium" or "lettucene," and its use was revived by naturist and alternative movements.
How to identify Lactuca virosa in nature
Identify the wild lettuce requires observing several key features:
- Usual height of 1 to 2 meters, with a smooth, hollow, and easily pierced stem. Also know the properties of mallow.
- Elongated, lanceolate leaves with toothed or thorny margins, arranged along the stemThe underside of the leaf has fine hairs on the central vein.
- Pale yellow flowering, with heads reminiscent of dandelions, emerging in spikes at the top of the plant.
- Exudation of milky white latex and bitter when cutting stems or leaves.
- Small, black fruits (achenes), which facilitate dispersal by the wind.
The plant usually prefers riverbanks, roads, and disturbed terrain, so it is relatively easy to find in warm, well-drained, and sunny soils.
Comparison with other species of the genus Lactuca
Although Lactuca virosa is the species best known for its medicinal properties, there are other related species such as lactuca serriola (prickly lettuce), whose latex can also be used, although with less sedative potency. lactuca sativa, on the other hand, corresponds to the usual salad lettuce and lacks significant narcotic or calming effects.
A fundamental difference lies in the morphology of the leaves: while the lactuca virosa It has smooth leaves but with slightly spiny margins, lactuca serriola It shows more clearly serrated edges and a more thorny appearance. Explore the best plants to plant in May.
Risks, contraindications and safety considerations
Although the lactucarium and wild lettuce preparations do not present a dependency profile comparable to opiates, they can cause Adverse effects when consumed in excess or without proper advice. Possible risks include:
- Excessive drowsiness and dizziness.
- Respiratory collapse at high doses.
- Anaphrodisiac effect after prolonged and continued use, it can alter libido.
- Gastric irritation or allergic reactions in sensitive people.
It is not recommended for use in pregnant or nursing women, young children, or people with severe respiratory illnesses or severe psychiatric disorders. If in doubt, it is always advisable to consult a healthcare professional before using Lactuca virosa preparations.
Collection, conservation and preparation of preparations
The extraction of lactucarium It is made by making incisions in the stem's lactiferous vessels, collecting the exuded latex and allowing it to oxidize and solidify in the air. This dry extract can be used as is or dissolved in infusions or tinctures.
The leaves and stems can also be harvested and dried for later preparations. It's important to harvest the plant during the flowering phase to maximize the concentration of active ingredients.
Among the most common home methods are:
- Infusion of dried leaves, made from a small amount of plant material per cup of hot water.
- Macerated in alcohol to obtain concentrated tinctures.
- Decoction of fresh stems and leaves to make homemade syrups.
Storage should be carried out in cool, dry places protected from light to preserve the volatile compounds and the effectiveness of the preparations.
Current importance and perspectives of use
Today, Lactuca virosa maintains its relevance in phytotherapy and alternative medicine, especially as a Support for nighttime rest, nerve relaxation, and management of minor discomfortAlthough it has been largely displaced by synthetic pharmaceuticals, it remains valued by those who prefer natural options or seek traditional remedies backed by centuries of empirical use.
Contemporary research continues to analyze the mechanisms of action of its active ingredients and their potential application in new phytotherapeutic formulas.
La lactuca virosa It represents much more than a simple wild plant: it is a symbol of traditional European and Asian medicine, a botanical resource of incalculable ethnobotanical value, and a natural alternative to hypnotics and sedatives. Identifying it and understanding its responsible use allows you to enjoy its historical and current benefits, always with the respect and caution that any natural medicinal resource deserves.
